Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol
نویسندگان
چکیده
منابع مشابه
Curcumin Mitigates Radiation-induced Lung Pneumonitis and Fibrosis in Rats
Radiation-induced lung injury is one of the most prominent factors that interfere with chest cancer radiotherapy, and poses a great threat to patients exposed to total body irradiation. Upregulation of pro-oxidant enzymes is one of the main mechanisms through which the late effects of ionizing radiation on lung injury can be exerted. Interleukin (IL)-4 and IL-13 are two important cytokines that...
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PURPOSE Radiotherapy is currently one of the main treatment modalities for head and neck cancer; however, it also results in severe toxicity to the normal tissue, to the detriment of patients. This study aimed to investigate whether alpha lipoic acid (ALA) could protect against radiation-induced oral mucositis in a rat model. RESULTS On post-irradiation days 4 and 7, the epithelial layer on o...
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Introduction: The use of lopinavir/ritonavir (LPV/r) has decreased morbidity and mortality due to human immunodeficiency virus (HIV); however its use could be impaired by hepatotoxicity. Therefore, this study was designed to investigate the effects of melatonin (MT) and alpha lipoic acid (ALA) on LPV/r-induced hepatotoxicity in male albino rats. Methods: Rats were divided into groups and treate...
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Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease. This has prompted several investigations into the use of antioxidants as a complementary therapeutic approach. Alpha lipoic acid, a naturally occurring dithiol compound which plays an essential role in mitochondrial bioenergetic rea...
متن کاملProtective effects of alpha-lipoic Acid on oleic Acid-induced acute lung injury in rats.
BACKGROUND Oxidative stress is believed to be an important factor in the pathogenesis of acute lung injury (ALI). AIMS The aim of this study was to investigate the possible protective role of alpha-lipoic acid (α-LA) on oleic acid (OA)-induced ALI in rats. STUDY DESIGN Animal experiment. METHODS A total of thirty-five rats were divided into five groups in the study. Group 1 served as a co...
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ژورنال
عنوان ژورنال: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
سال: 2020
ISSN: 1871-5230
DOI: 10.2174/1871523018666190319144020